Jefferson is a town located in the Maryland region of the United States. During the most recent census, Jefferson had a population of 2,111. Jefferson is the 226th most poplulated city in the Maryland region, the 9,823rd most populated city in the United States and the 43,042nd most populated city in the world. Jefferson is in the America/New York timezone which is 4 hours behind UTC. Jefferson adjusts the hour with daylight savings time during the winter months.